Antineoplastic drug CAS 1420477-60-6 AcalabrutinibProduct
nameAcalabrutinibCas No.1420477-60-6Molecular
FormulaC26H23N7O2AppearanceWhite crystalline powder
Acalabrutinib, also known as ACP-196, is an orally available Bruton
tyrosine kinase (BTK) inhibitor with potential antitumor
activity.When applied, ACP-196 inhibits BTK activity and blocks
activation of the B cell antigen receptor (BCR) signaling
pathway.This prevents B cell activation and BTK-mediated activation
of downstream survival pathways.This leads to inhibition of the
growth of malignant B cells that overexpress BTK.BTK is a member of
the Src associated BTK/TEC cytoplasmic tyrosine kinase family and
is overexpressed in B-cell malignancies.It plays an important role
in B lymphocyte development, activation, signaling, proliferation,
and survival. /* January 22, 2024 19:08:37
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