Antineoplastic Drug CAS 1420477-60-6 Acalabrutinib/ACP-196

Antineoplastic drug CAS 1420477-60-6 AcalabrutinibProduct nameAcalabrutinibCas No.1420477-60-6Molecular FormulaC26H23N7O2AppearanceWhite crystalline powder  Acalabrutinib, also known as ACP-196, is an orally available Bruton tyrosine kinase (BTK) inhibitor with potential antitumor activity.When applied, ACP-196 inhibits BTK activity and blocks activation of the B cell antigen receptor (BCR) signaling pathway.This prevents B cell activation and BTK-mediated activation of downstream survival pathways.This leads to inhibition of the growth of malignant B cells that overexpress BTK.BTK is a member of the Src associated BTK/TEC cytoplasmic tyrosine kinase family and is overexpressed in B-cell malignancies.It plays an important role in B lymphocyte development, activation, signaling, proliferation, and survival.  /* January 22, 2024 19:08:37 */!function(){function s(e,r){var a,o={};try{e&&e.split(",").forEach(function(e,t){e&&(a=e.match(/(.*?):(.*)$/))&&1